|
|
5-hydroxy-L-tryptophan + H+ <=> serotonin + CO2
|
4.1.1.28
aromatic-L-amino-acid decarboxylase
4.1.1.53
phenylalanine decarboxylase
|
–
–
|
MK
|
|
BRENDA:
BR49520
KEGG:
R02701
MetaCyc:
RXN3DJ-170
|
|
|
|
serotonin + O2 + H2O <=> (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
|
1.4.3.21
primary-amine oxidase
1.4.3.4
monoamine oxidase
|
–
–
|
MK
|
|
BRENDA:
BS260304
KEGG:
R02908
MetaCyc:
RXN-10778
SABIO-RK:
2768
|
|
|
|
acetyl-CoA + serotonin <=> H+ + CoA + N-acetylserotonin
|
2.3.1.5
arylamine N-acetyltransferase
2.3.1.87
aralkylamine N-acetyltransferase
|
–
–
|
MK
|
|
BRENDA:
BS320965
KEGG:
R02911
MetaCyc:
RXN3DJ-35528
SABIO-RK:
2771
|
|
|
|
serotonin + 3''-phosphoadenylyl-sulfate <=> adenosine_3,5''-bisphosphate + 3-(2-aminoethyl)-5-indoxyl_sulfate + H+
|
2.8.2.1
aryl sulfotransferase
|
–
|
M
|
|
BRENDA:
BS360074
MetaCyc:
RXN-10777
|
|
|
|
caffeoyl-CoA + serotonin <=> (2E)-3-(3,4-dihydroxyphenyl)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]prop-2-enamide + CoA + H+
|
2.3.1.110
tyramine N-feruloyltransferase
2.3.1.M35
|
–
–
|
M
|
|
BRENDA:
BS376441
MetaCyc:
RXN-8709
|
|
|
|
serotonin + UDP-glucuronate <=> Tryptamine_5-O-beta-D-glucuronide + UDP
|
2.4.1.17
glucuronosyltransferase
|
–
|
|
|
BRENDA:
BS322184
SABIO-RK:
11559
|
|
|
|
4-coumaroyl-CoA + serotonin <=> H+ + N-(4-coumaroyl)tryptamine + CoA
|
2.3.1.M35
|
–
|
M
|
|
MetaCyc:
RXN-8711
SABIO-RK:
14776
|
|
|
|
serotonin + O2 <=> Formyl-5-hydroxykynurenamine
|
1.13.11.52
indoleamine 2,3-dioxygenase
|
–
|
K
|
|
KEGG:
R02909
SABIO-RK:
2769
|
|
|
|
S-adenosyl-L-methionine + serotonin <=> S-adenosyl-L-homocysteine + N-methylserotonin
|
2.1.1.49
amine N-methyltransferase
|
–
|
K
|
|
KEGG:
R02910
SABIO-RK:
2770
|
|
|
|
serotonin + 5-methyltetrahydrofolate <=> 5-methoxytryptamine + tetrahydrofolate
|
2.1.1
|
–
|
K
|
|
KEGG:
R02912
|
|
|
|
L-glutaminyl-peptide + serotonin <=> [protein]_N6-[(5-hydroxy-1H-indol-3-yl)ethyl]-L-glutamine + NH3
|
2.3.2.13
protein-glutamine gamma-glutamyltransferase
|
–
|
|
|
MetaCyc:
RXN-19236
|
|
|
|
tryptamine + reduced_[NADPH-hemoprotein_reductase] + O2 <=> serotonin + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.14
|
–
|
M
|
|
MetaCyc:
RXN-8707
|
|
|
|
feruloyl-CoA + serotonin <=> H+ + feruloylserotonin + CoA
|
2.3.1.M35
|
–
|
M
|
|
MetaCyc:
RXN-8710
|
|
|
|
cinnamoyl-CoA + serotonin <=> cinnamoylserotonin + CoA + H+
|
2.3.1.M35
|
–
|
M
|
|
MetaCyc:
RXN-8712
|
|
|
|
dimethylallyl_diphosphate + serotonin <=> diphosphate + 4-(3-methylbut-2-enyl)-serotonin
|
2.5.1.34
4-dimethylallyltryptophan synthase
|
–
|
|
|
BRENDA:
BS388577
|
|
|
|
serotonin + O2 <=> (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3
|
1.4.3.4
monoamine oxidase
4.1.1.28
aromatic-L-amino-acid decarboxylase
|
–
–
|
|
|
BRENDA:
BS367929
|
|
|
|
serotonin + H2O + 2,6-dichlorophenolindophenol <=> 6-hydroxy-4H-indol-3-yl-acetaldehyde + NH3 + reduced_2,6-dichlorophenolindophenol
|
1.4.9.2
aralkylamine dehydrogenase (azurin)
|
–
|
|
|
BRENDA:
BS374628
|
|
|
|
serotonin + H2O2 <=> serotonin_dimer + H2O
|
1.11.2.2
myeloperoxidase
|
–
|
|
|
BRENDA:
BS415311
|
|
|
|
serotonin + H2O2 + H+ <=> tryptamine-4,5-dione + H2O
|
1.11.2.2
myeloperoxidase
|
–
|
|
|
BRENDA:
BS440400
|
|
|
|
serotonin + S-adenosyl-L-methionine <=> S-adenosyl-L-homocysteine + 5-methoxytryptamine
|
2.1.1.4
acetylserotonin O-methyltransferase
2.1.1.68
caffeate O-methyltransferase
|
–
–
|
|
|
BRENDA:
BS289656
|
|
|
|
serotonin + O2- <=> tryptamine-4,5-dione + H2O
|
1.11.2.2
myeloperoxidase
|
–
|
|
|
BRENDA:
BS415312
|
|
|
|
serotonin + acceptor + H2O <=> (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + reduced_acceptor
|
1.4.9.2
aralkylamine dehydrogenase (azurin)
|
–
|
|
|
BRENDA:
BS261194
|
|
|
|
3''-phosphoadenylylsulfate + serotonin <=> adenosine_3'',5''-bisphosphate + serotonin_N-sulfate
|
2.8.2.3
amine sulfotransferase
|
–
|
|
|
BRENDA:
BS360454
|
|
|
|
serotonin + secologanin <=> (4S,5R,6S)-4-((S)-6-hydroxy-2,3,4,9-tetrahydro-1H-b-carbolin-1-ylmethyl)-6-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-5-vinyl-5,6-dihydro-4H-pyran-3-carboxylic_acid_methyl_ester + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS381070
|
|
|
|
serotonin + secologanin <=> 5-hydroxy-3-alpha(S)-strictosidine + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS401888
|
|
|
|
benzoyl-CoA + serotonin <=> N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]benzamide + CoA
|
not assigned
|
–
|
|
|
SABIO-RK:
14782
|
|